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Am J Geriatr Psychiatry 1:244-248, August 1993
© 1993 American Association for Geriatric Psychiatry
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CLINICAL AND RESEARCH REPORT

Response to Combination Cholinergic/Noradrenergic Treatments in a Patient With Alzheimer's Disease

Paul S. Aisen, M.D., Linda M. Bierer, M.D., Michael Davidson, M.D., Theresa M. Ryan, B.S., Ranti Kaminsky, M.D., and Kenneth L. Davis, M.D.

Department of Psychiatry, Box 1230, Mt. Sinai Medical Center, 1 Gustave L. Levy PI., New York, NY 10029.

A patient with probable Alzheimer's disease participated in four studies involving cholinergic and combination cholinergic/noradrenergic treatment regimens. This patient demonstrated clinically significant improvement only with the combination of physostigmine and clonidine. The implications of these findings are discussed with regard to strategies for neurotransmitter augmentation therapy for Alzheimer's disease.







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Copyright © 1993 American Association for Geriatric Psychiatry